Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 1.00 |
| ▸ | CCND1 | P24385 | 17/20 | 1.00 |
| ▸ | CCND2 | P30279 | 15/20 | 1.00 |
| ▸ | CCND3 | P30281 | 15/20 | 1.00 |
| ▸ | CDK2 | P24941 | 11/20 | 0.92 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.92 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.92 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.92 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.92 |
| ▸ | PAK4 | O96013 | 1/20 | 0.92 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.92 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.92 |
| ▸ | CDK1 | P06493 | 6/20 | 0.90 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.90 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.90 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.90 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.90 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.90 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.90 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5268285 | 0.96 | CDK4 (0.92) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL30418772 | 0.96 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5262935 | 0.96 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL1890595 | 0.95 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5264602 | 0.95 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5265827 | 0.94 | CDK4 (0.89) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5263689 | 0.94 | CDK4 (0.89) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5265688 | 0.93 | CDK4 (0.89) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5263754 | 0.93 | CDK4 (0.87) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5262313 | 0.91 | CDK4 (0.83) | CDK4CCND1CCND2CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806348-A2 | Pyrido (2,3-D)Pyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-07-11 | — | — | EP | claimed |
| US-6498163-B1 | POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES AND GROWTH FACTOR MEDIATED KINASES; CANCER, RESTENOSIS, ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY | 2002-12-24 | — | — | US | claimed |
| EP-0964864-A2 | PYRIDO 2,3-D] PYRIMIDINES AND 4-AMINOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-22 | — | — | EP | claimed |
| WO-1998033798-A2 | PYRIDO[2,3-D]PYRIMIDINES AND 4-AMINO-PYRIMIDINES AS INHIBITORS OF CELL PROLIFERATION | WARNER LAMBERT COMPANY (US) | 1998-08-06 | — | — | WO | claimed |
| EP-1806348-A2 | Pyrido (2,3-D)Pyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-07-11 | — | — | EP | disclosed |
| US-6498163-B1 | POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES AND GROWTH FACTOR MEDIATED KINASES; CANCER, RESTENOSIS, ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY | 2002-12-24 | — | — | US | disclosed |