Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | FOXM1 | Q08050 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1984254 | 0.98 | KDM4E (0.64) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1988261 | 0.97 | KDM4E (0.66) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL7140903 | 0.82 | KDM4E (0.79) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL23074654 | 0.81 | KDM4E (0.88) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL23074658 | 0.81 | KDM4E (0.88) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL2352175 | 0.81 | KDM4E (0.69) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL7135308 | 0.81 | KDM4E (0.81) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL12204238 | 0.80 | KDM4E (0.70) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL11876550 | 0.78 | KDM4E (0.58) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL1299936 | 0.78 | KDM4E (0.64) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796664-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006047017-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |