Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 19/20 | 0.52 |
| ▸ | CCND1 | P24385 | 19/20 | 0.52 |
| ▸ | CCND2 | P30279 | 19/20 | 0.52 |
| ▸ | CCND3 | P30281 | 19/20 | 0.52 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264857 | 1.00 | JAK3 (0.59) | JAK3CDK4CCND1CCND2CCND3 | |
| SCHEMBL5264353 | 0.87 | CDK4 (0.67) | JAK3CDK4CCND1CCND2CCND3 | |
| SCHEMBL5264351 | 0.87 | CDK4 (0.67) | JAK3CDK4CCND1CCND2CCND3 | |
| SCHEMBL5267858 | 0.84 | JAK3 (0.63) | JAK3CDK4CCND1CCND2CCND3 | |
| SCHEMBL5263544 | 0.83 | CDK4 (0.68) | JAK3CDK4CCND1CCND2CCND3 | |
| SCHEMBL5263548 | 0.83 | CDK4 (0.68) | JAK3CDK4CCND1CCND2CCND3 | |
| SCHEMBL5262748 | 0.82 | CDK4 (0.62) | JAK3CDK4CCND1CCND2CCND3 | |
| SCHEMBL5268149 | 0.81 | CDK4 (0.70) | JAK3CDK4CCND1CCND2CCND3 | |
| SCHEMBL5268153 | 0.81 | CDK4 (0.70) | JAK3CDK4CCND1CCND2CCND3 | |
| SCHEMBL5262614 | 0.81 | JAK3 (0.61) | JAK3CDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806348-A2 | Pyrido (2,3-D)Pyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-07-11 | — | — | EP | disclosed |
| US-6498163-B1 | POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES AND GROWTH FACTOR MEDIATED KINASES; CANCER, RESTENOSIS, ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY | 2002-12-24 | — | — | US | disclosed |
| EP-1255755-A1 | PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE | WARNER-LAMBERT COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001055148-A1 | PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE | WARNER-LAMBERT COMPANY (US) | 2001-08-02 | — | — | WO | disclosed |