Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 17/20 | 0.65 |
| ▸ | ALPL | P05186 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527505 | 0.86 | CYP17A1 (0.71) | CYP17A1ALPL | |
| SCHEMBL526947 | 0.85 | CYP17A1 (0.66) | CYP17A1ALPL | |
| SCHEMBL526359 | 0.83 | CYP17A1 (0.66) | CYP17A1 | |
| SCHEMBL527545 | 0.82 | CYP17A1 (0.67) | CYP17A1 | |
| SCHEMBL527237 | 0.81 | CYP17A1 (0.70) | CYP17A1ALPL | |
| SCHEMBL526211 | 0.81 | CYP17A1 (0.70) | CYP17A1ALPL | |
| SCHEMBL527272 | 0.81 | CYP17A1 (0.70) | CYP17A1 | |
| SCHEMBL526745 | 0.81 | CYP17A1 (0.70) | CYP17A1ALPL | |
| SCHEMBL527191 | 0.81 | CYP17A1 (0.70) | CYP17A1 | |
| SCHEMBL527242 | 0.81 | CYP17A1 (0.73) | CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598481-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | Bristol-Myers Squibb Company (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012015723-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-02 | — | — | WO | disclosed |