Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 4/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4320733 | 0.94 | AURKA (0.60) | AURKAAURKBGFERNPC1RAB9A | |
| SCHEMBL4320741 | 0.94 | AURKA (0.60) | AURKAAURKBGFERNPC1RAB9A | |
| SCHEMBL4314913 | 0.93 | AURKA (0.58) | AURKAAURKBGFERNPC1RAB9A | |
| SCHEMBL4314905 | 0.93 | AURKA (0.58) | AURKAAURKBGFERNPC1RAB9A | |
| SCHEMBL4326949 | 0.91 | AURKA (0.58) | AURKAAURKBGFERNPC1RAB9A | |
| SCHEMBL4326955 | 0.91 | AURKA (0.58) | AURKAAURKBGFERNPC1RAB9A | |
| SCHEMBL4316361 | 0.90 | AURKA (0.56) | AURKAAURKBNPC1RAB9AFLT3 | |
| SCHEMBL4316358 | 0.90 | AURKA (0.56) | AURKAAURKBNPC1RAB9AFLT3 | |
| SCHEMBL4315080 | 0.89 | AURKA (0.59) | AURKAAURKBGFERNPC1RAB9A | |
| SCHEMBL4313589 | 0.89 | AURKA (0.60) | AURKAAURKBGFERNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |