Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053643 | 0.90 | PDE4B (0.45) | PDE4BTBXAS1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL4059717 | 0.88 | PDE4B (0.47) | PDE4BTBXAS1GAAHTTSMN1; SMN2 | |
| SCHEMBL4051234 | 0.88 | PDE4B (0.52) | PDE4BTBXAS1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL4054383 | 0.85 | PDE4B (0.54) | PDE4BTBXAS1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL5264222 | 0.85 | PDE4B (0.41) | PDE4BTBXAS1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL4055082 | 0.82 | PDE4B (0.47) | PDE4BTBXAS1ALDH1A1LMNAGAA | |
| SCHEMBL4057192 | 0.82 | PDE4B (0.49) | PDE4BTBXAS1GAAMEN1KMT2A | |
| SCHEMBL4052008 | 0.82 | PDE4B (0.45) | PDE4BTBXAS1L3MBTL1MAPTGAA | |
| SCHEMBL4051345 | 0.82 | PDE4B (0.50) | PDE4BTBXAS1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL4052285 | 0.82 | PDE4B (0.46) | PDE4BTBXAS1ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781621-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2007-05-09 | — | — | EP | disclosed |
| WO-2005123693-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | disclosed |