Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4901768 | 0.80 | DAO (0.46) | DAO | |
| SCHEMBL5266303 | 0.77 | DAO (0.45) | DAO | |
| SCHEMBL4910360 | 0.75 | PTPN1 (0.49) | — | |
| SCHEMBL29717252 | 0.75 | TOP2A (0.56) | NPC1PKMRAB9ADAO | |
| SCHEMBL4903739 | 0.74 | SCN10A (0.51) | DAO | |
| SCHEMBL4907263 | 0.74 | IKBKE (0.44) | DAO | |
| SCHEMBL5256434 | 0.73 | NPC1 (0.42) | NPC1PKMRAB9ADAO | |
| SCHEMBL4909723 | 0.73 | TOP2A (0.49) | — | |
| SCHEMBL4907614 | 0.72 | TOP2A (0.42) | DAO | |
| SCHEMBL5263131 | 0.72 | HPGD (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861393-A2 | PYRROLE DERIVATIVES AS DNA GYRASE AND TOPOISOMERASE INHIBITORS | AstraZeneca AB (SE) | 2007-12-05 | — | — | EP | claimed |
| WO-2006092599-A2 | PYRROLE DERIVATIVES AS DNA GYRASE AND TOPOISOMERASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-09-08 | — | — | WO | claimed |