Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264738 | 0.93 | MAPK14 (0.53) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3518147 | 0.90 | MAPK14 (0.65) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3522858 | 0.89 | MAPK14 (0.76) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL5435303 | 0.88 | MAPK14 (0.60) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL5441496 | 0.86 | MAPK14 (0.61) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3525265 | 0.83 | MAPK14 (0.56) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3526016 | 0.82 | MAPK14 (0.67) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3522512 | 0.82 | MAPK14 (0.65) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3523052 | 0.82 | MAPK14 (0.74) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3520948 | 0.82 | MAPK14 (0.59) | MAPK14MAPK11ROCK2MAPK12STRADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753731-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | Pharmacia Corporation (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2004087677-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | PHARMACIA CORPORATION (US) | 2004-10-14 | — | — | WO | disclosed |