Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3519707 | 0.89 | MAPK14 (0.59) | MAPK14KDM4EHPGDNPSR1MAPT | |
| SCHEMBL3521113 | 0.86 | MAPK14 (0.58) | MAPK14KDM4EHPGDNPSR1MAPT | |
| SCHEMBL3521534 | 0.85 | MAPK14 (0.67) | MAPK14KDM4EHPGDNPSR1MAPT | |
| SCHEMBL3526494 | 0.83 | MAPK14 (0.49) | MAPK14KDM4EHPGDNPSR1MAPT | |
| SCHEMBL3521221 | 0.81 | MAPK14 (0.48) | MAPK14KDM4EHPGDNPSR1MAPT | |
| SCHEMBL3520032 | 0.81 | MAPK14 (0.51) | MAPK14KDM4EHPGDNPSR1MAPT | |
| SCHEMBL3521293 | 0.81 | MAPK14 (0.46) | MAPK14KDM4EHPGDNPSR1MAPT | |
| SCHEMBL3519362 | 0.81 | MAPK14 (0.51) | MAPK14KDM4EHPGDNPSR1MAPT | |
| SCHEMBL3520704 | 0.81 | MAPK14 (0.53) | MAPK14KDM4EHPGDNPSR1MAPT | |
| SCHEMBL3518775 | 0.81 | MAPK14 (0.69) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753731-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | Pharmacia Corporation (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2004087677-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | PHARMACIA CORPORATION (US) | 2004-10-14 | — | — | WO | disclosed |