Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3522477 | 0.93 | MAPK14 (0.43) | MAPK14HTR2AHTR2CSLC6A4 | |
| SCHEMBL3524990 | 0.90 | MAPK14 (0.48) | MAPK14 | |
| SCHEMBL3525655 | 0.90 | MAPK14 (0.53) | MAPK14 | |
| SCHEMBL3519190 | 0.89 | MAPK14 (0.58) | MAPK14 | |
| SCHEMBL3520390 | 0.89 | MAPK14 (0.48) | MAPK14 | |
| SCHEMBL5270348 | 0.88 | MAPK14 (0.47) | MAPK14 | |
| SCHEMBL5265292 | 0.87 | MAPK14 (0.46) | MAPK14 | |
| SCHEMBL5268160 | 0.87 | MAPK14 (0.54) | MAPK14 | |
| SCHEMBL3521433 | 0.87 | MAPK14 (0.55) | MAPK14HTR2AHTR2CSLC6A4 | |
| SCHEMBL3521387 | 0.87 | MAPK14 (0.47) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753731-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | Pharmacia Corporation (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2004087677-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | PHARMACIA CORPORATION (US) | 2004-10-14 | — | — | WO | disclosed |