Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264919 | 0.90 | MAPK14 (0.51) | MAPK14 | |
| SCHEMBL3524524 | 0.88 | MAPK14 (0.56) | MAPK14MAPK11MAPK1MAPKAPK5 | |
| SCHEMBL5267652 | 0.88 | MAPK14 (0.54) | MAPK14MAPK1MAPKAPK5 | |
| SCHEMBL3522356 | 0.86 | MAPK14 (0.51) | MAPK14MAPK11MAPK1MAPKAPK5 | |
| SCHEMBL3522967 | 0.85 | MAPK14 (0.67) | MAPK14MAPK11 | |
| Trifluoroacetic Acid SCHEMBL3523297 | 0.85 | MAPK14 (0.48) | MAPK14MAPK11MAPK1MAPKAPK5 | |
| SCHEMBL31079728 | 0.83 | MAPK14 (0.73) | MAPK14 | |
| SCHEMBL5356051 | 0.83 | MAPK14 (0.48) | MAPK14MAPK11MAPK1MAPKAPK5 | |
| SCHEMBL5364747 | 0.81 | MAPK14 (0.46) | MAPK14MAPK11MAPK1MAPKAPK5 | |
| SCHEMBL3527409 | 0.81 | MAPK14 (0.46) | MAPK14MAPK11MAPK1MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753731-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | Pharmacia Corporation (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2004087677-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | PHARMACIA CORPORATION (US) | 2004-10-14 | — | — | WO | disclosed |