SCHEMBL5267328

SCHEMBL5267328

O=c1ccc2cnc(Nc3ccc(N4CCCCC4)cc3)nc2n1CCc1cccs1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 15/20 0.67
CCND1 P24385 15/20 0.67
CCND2 P30279 14/20 0.67
CCND3 P30281 14/20 0.67
CCNA2 P20248 7/20 0.58
CDK2 P24941 7/20 0.58
CCNE2 O96020 6/20 0.58
CCNE1 P24864 6/20 0.58
CCNA1 P78396 6/20 0.58
CCNB2 O95067 5/20 0.58
CDK1 P06493 5/20 0.58
CCNB1 P14635 5/20 0.58
CCNB3 Q8WWL7 5/20 0.58
FGFR1 P11362 4/20 0.55
FGFR2 P21802 4/20 0.55
FGFR4 P22455 4/20 0.55
FGFR3 P22607 4/20 0.55
PAK4 O96013 1/20 0.54
PAK1 Q13153 1/20 0.54
PKN1 Q16512 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5267700 0.93 CDK4 (0.72) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL5265718 0.91 CDK4 (0.69) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL5266229 0.86 CDK4 (0.67) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL5263664 0.85 CDK4 (0.73) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL5270146 0.84 JAK3 (0.59) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL7498846 0.82 CDK4 (0.67) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL5268323 0.82 CDK4 (0.67) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL4714685 0.81 CDK4 (0.74) CDK4CCND1CCND2CCND3CCNA2
Hydrochloric Acid SCHEMBL5263510 0.81 CDK4 (0.73) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL5266540 0.81 CDK4 (0.76) CDK4CCND1CCND2CCND3CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1806348-A2 Pyrido (2,3-D)Pyrimidines as inhibitors of cellular proliferation Warner-Lambert Company LLC (US) 2007-07-11 EP disclosed
US-6498163-B1 POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES AND GROWTH FACTOR MEDIATED KINASES; CANCER, RESTENOSIS, ATHEROSCLEROSIS WARNER-LAMBERT COMPANY 2002-12-24 US disclosed