Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | LTK | P29376 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14395908 | 0.88 | HSP90AA1 (0.54) | HSP90AA1MEN1HSP90AB1METMAPT | |
| SCHEMBL14456102 | 0.84 | HSP90AA1 (0.66) | HSP90AA1MEN1HSP90AB1METMAPT | |
| SCHEMBL14456069 | 0.83 | HSP90AA1 (0.65) | HSP90AA1MEN1HSP90AB1METMAPT | |
| SCHEMBL14456101 | 0.81 | HSP90AA1 (0.60) | HSP90AA1MEN1HSP90AB1METMAPT | |
| SCHEMBL14396177 | 0.80 | HSP90AA1 (0.61) | HSP90AA1MEN1HSP90AB1METMAPT | |
| SCHEMBL14456150 | 0.80 | HSP90AA1 (0.61) | HSP90AA1MEN1HSP90AB1METMAPT | |
| SCHEMBL14396179 | 0.79 | HSP90AA1 (0.61) | HSP90AA1MEN1HSP90AB1METMAPT | |
| SCHEMBL5268016 | 0.79 | HSP90AA1 (0.60) | HSP90AA1MEN1HSP90AB1METMAPT | |
| SCHEMBL5273456 | 0.77 | HSP90AA1 (0.58) | HSP90AA1MEN1HSP90AB1METMAPT | |
| SCHEMBL14396346 | 0.77 | HSP90AA1 (0.61) | HSP90AA1MEN1HSP90AB1METMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456180-B1 | 3-(2,4)DIHYDROXYPHENYL-4-PHENYLPYRAZOLES AND THEIR MEDICAL USE | VERNALIS CAMBRIDGE LTD (GB) | 2007-10-03 | — | — | EP | disclosed |
| US-7247734-B2 | 3,4-diarylpyrazoles and their use in the therapy of cancer | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-07-24 | — | — | US | disclosed |
| EP-1456180-A1 | 3,4-DIARYLPYRAZOLES AND THEIR USE IN THE THERAPY OF CANCER | Vernalis (Oxford) Ltd (GB) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003055860-A1 | 3,4-DIARYLPYRAZOLES AND THEIR USE IN THE THERAPY OF CANCER | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2003-07-10 | — | — | WO | disclosed |