Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5268022 | 0.83 | CHEK1 (0.31) | LRRK2 | |
| SCHEMBL5267152 | 0.80 | HSP90AA1 (0.38) | — | |
| SCHEMBL5269531 | 0.80 | KDM4E (0.42) | — | |
| SCHEMBL5266777 | 0.76 | HSP90AA1 (0.33) | — | |
| SCHEMBL5269715 | 0.76 | LRRK2 (0.35) | LRRK2 | |
| SCHEMBL5269354 | 0.76 | HSP90AA1 (0.48) | — | |
| SCHEMBL5271929 | 0.76 | HSP90AA1 (0.47) | — | |
| SCHEMBL5272531 | 0.75 | CHEK1 (0.40) | LRRK2TTK | |
| SCHEMBL5272249 | 0.75 | MEN1 (0.39) | — | |
| SCHEMBL5273258 | 0.75 | HSP90AA1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456180-B1 | 3-(2,4)DIHYDROXYPHENYL-4-PHENYLPYRAZOLES AND THEIR MEDICAL USE | VERNALIS CAMBRIDGE LTD (GB) | 2007-10-03 | — | — | EP | disclosed |
| US-7247734-B2 | 3,4-diarylpyrazoles and their use in the therapy of cancer | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-07-24 | — | — | US | disclosed |
| EP-1456180-A1 | 3,4-DIARYLPYRAZOLES AND THEIR USE IN THE THERAPY OF CANCER | Vernalis (Oxford) Ltd (GB) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003055860-A1 | 3,4-DIARYLPYRAZOLES AND THEIR USE IN THE THERAPY OF CANCER | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2003-07-10 | — | — | WO | disclosed |