Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6728260 | 0.89 | GRM2 (0.66) | GRM2 | |
| SCHEMBL5267451 | 0.88 | GRM2 (0.62) | GRM2 | |
| SCHEMBL27685265 | 0.86 | GRM2 (0.45) | GRM2 | |
| SCHEMBL5268438 | 0.82 | GRM2 (0.65) | GRM2 | |
| SCHEMBL5268742 | 0.80 | GRM2 (0.62) | GRM2 | |
| SCHEMBL6733319 | 0.80 | GRM2 (0.46) | GRM2 | |
| SCHEMBL6738312 | 0.78 | GRM2 (0.71) | GRM2 | |
| SCHEMBL6731061 | 0.76 | GRM2 (0.56) | GRM2 | |
| SCHEMBL6730900 | 0.75 | GRM2 (0.64) | GRM2 | |
| SCHEMBL27685188 | 0.74 | GRM2 (0.52) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809608-A1 | PYRIMIDINE AND QUINOLINE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-07-25 | — | — | EP | claimed |
| WO-2006049968-A1 | PYRIMIDINE AND QUINOLINE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-05-11 | — | — | WO | claimed |
| EP-1809608-A1 | PYRIMIDINE AND QUINOLINE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006049968-A1 | PYRIMIDINE AND QUINOLINE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-05-11 | — | — | WO | disclosed |