SCHEMBL5268736

SCHEMBL5268736

O=C(O)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)[nH]1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 2/20 0.58
MAPK14 Q16539 7/20 0.50
MAPK13 O15264 6/20 0.50
MAPK12 P53778 6/20 0.50
MAPK11 Q15759 6/20 0.50
GCGR P47871 5/20 0.50
RAF1 P04049 1/20 0.49
PTGS1 P23219 4/20 0.48
PTGS2 P35354 4/20 0.48
CDH1 P12830 1/20 0.45
APC P25054 1/20 0.45
CTNNB1 P35222 1/20 0.45
TCF7L2 Q9NQB0 1/20 0.45
KDM4E B2RXH2 3/20 0.44
ALDH1A1 P00352 2/20 0.44
GLA P06280 2/20 0.44
GAA P10253 2/20 0.44
HPGD P15428 2/20 0.44
KMT2A Q03164 2/20 0.44
POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5274289 0.84 KDM4E (0.58) CNR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL5267660 0.80 MAPT (0.62) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL4079971 0.78 CNR1 (0.59) CNR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL2029325 0.77 MAPK14 (0.56) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL7046157 0.77 CNR1 (0.49) CNR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL2027320 0.77 CNR1 (0.55) CNR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL5848384 0.76 BRAF (0.59) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL2028098 0.75 CNR1 (0.56) CNR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL11227523 0.75 KDM4E (0.51) CNR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL3956357 0.74 MAPK13 (0.74) MAPK14MAPK13MAPK12MAPK11GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1844020-A1 HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTOR LIGANDS Exelixis, Inc. (US) 2007-10-17 EP claimed
WO-2007024744-A2 HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTOR LIGANDS EXELIXIS, INC. (US) 2007-03-01 WO claimed
WO-2006076202-A1 HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTORS LIGANDS EXELIXIS, INC. (US) 2006-07-20 WO claimed
EP-1844020-B1 HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTOR LIGANDS EXELIXIS INC (US) 2017-09-06 EP disclosed
EP-1844020-A1 HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTOR LIGANDS Exelixis, Inc. (US) 2007-10-17 EP disclosed
WO-2007024744-A2 HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTOR LIGANDS EXELIXIS, INC. (US) 2007-03-01 WO disclosed
WO-2006076202-A1 HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTORS LIGANDS EXELIXIS, INC. (US) 2006-07-20 WO disclosed