Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3525078 | 0.99 | MAPK14 (0.49) | MAPK14MAPK11HTR2AHTR2CSLC6A4 | |
| SCHEMBL5265660 | 0.85 | MAPK14 (0.53) | MAPK14MAPK11HTR2AHTR2CSLC6A4 | |
| SCHEMBL13602920 | 0.85 | MAPK14 (0.45) | MAPK14PREP | |
| Hydrochloric Acid SCHEMBL3518780 | 0.84 | MAPK14 (0.53) | MAPK14MAPK11HTR2AHTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL4377579 | 0.84 | MAPK14 (0.44) | MAPK14PREP | |
| SCHEMBL3522398 | 0.84 | MAPK14 (0.58) | MAPK14MAPK11 | |
| SCHEMBL3526927 | 0.84 | MAPK14 (0.57) | MAPK14MAPK11 | |
| SCHEMBL5270020 | 0.82 | MAPK14 (0.53) | MAPK14MAPK11 | |
| SCHEMBL3527712 | 0.82 | MAPK14 (0.53) | MAPK14MAPK11 | |
| SCHEMBL3524386 | 0.81 | MAPK14 (0.48) | MAPK14MAPK11HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753731-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | Pharmacia Corporation (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2004087677-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | PHARMACIA CORPORATION (US) | 2004-10-14 | — | — | WO | disclosed |