Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30149754 | 1.00 | TDP1 (0.48) | TDP1CA12CA1CA9KDM4E | |
| SCHEMBL9614447 | 0.99 | KDM4E (0.48) | TDP1CA12CA1CA9KDM4E | |
| SCHEMBL6858825 | 0.95 | NPY4R (0.46) | TDP1CA12CA1CA9KDM4E | |
| SCHEMBL29543910 | 0.93 | CA12 (0.47) | TDP1CA12CA1CA9KDM4E | |
| SCHEMBL7208685 | 0.93 | CA12 (0.47) | TDP1CA12CA1CA9KDM4E | |
| SCHEMBL7208677 | 0.93 | CA12 (0.47) | TDP1CA12CA1CA9KDM4E | |
| SCHEMBL18190281 | 0.92 | TDP1 (0.46) | TDP1CA12CA1CA9KDM4E | |
| SCHEMBL7204729 | 0.92 | KDM4E (0.48) | TDP1CA12CA1CA9KDM4E | |
| SCHEMBL8499114 | 0.92 | KDM4E (0.48) | TDP1CA12CA1CA9KDM4E | |
| SCHEMBL7204719 | 0.92 | KDM4E (0.48) | TDP1CA12CA1CA9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161266-A4 | MATRIPTASE, A SERINE PROTEASE AND ITS APPLICATIONS | UNIV GEORGETOWN (US) | 2007-09-19 | — | — | EP | disclosed |
| EP-1161266-A1 | MATRIPTASE, A SERINE PROTEASE AND ITS APPLICATIONS | GEORGETOWN UNIVERSITY (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000053232-A1 | MATRIPTASE, A SERINE PROTEASE AND ITS APPLICATIONS | GEORGETOWN UNIVERSITY (US) | 2000-09-14 | — | — | WO | disclosed |