Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.61 |
| ▸ | BRD4 | O60885 | 3/20 | 0.51 |
| ▸ | BACE1 | P56817 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19225201 | 0.87 | HDAC1 (0.77) | HDAC1HDAC6BRD4HDAC8KDM1A | |
| SCHEMBL31620872 | 0.86 | HDAC1 (0.62) | HDAC1HDAC6BRD4 | |
| SCHEMBL20572179 | 0.84 | NPC1 (0.49) | HDAC1HDAC6BACE1KDM1A | |
| SCHEMBL31620916 | 0.81 | HDAC1 (0.62) | HDAC1HDAC6BRD4BCHEHTR6 | |
| SCHEMBL7441606 | 0.80 | HDAC1 (0.52) | HDAC1HDAC6BRD4BCHEHTR6 | |
| SCHEMBL30673916 | 0.80 | HDAC1 (0.67) | HDAC1HDAC6BRD4KDM1A | |
| SCHEMBL26092309 | 0.80 | HDAC1 (0.67) | HDAC1HDAC6BRD4KDM1A | |
| SCHEMBL30910107 | 0.80 | HDAC1 (0.67) | HDAC1HDAC6BRD4KDM1A | |
| SCHEMBL30910116 | 0.79 | HDAC1 (0.76) | HDAC1HDAC6BRD4HDAC8KDM1A | |
| SCHEMBL26089401 | 0.79 | HDAC1 (0.76) | HDAC1HDAC6BRD4HDAC8KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056728-B1 | DIHYDRO-BENZO(1,4)OXAZINES AND TETRAHYDROQUINOXALINES | AVENTIS PHARMA LTD (GB) | 2007-11-21 | — | — | EP | disclosed |
| US-6632814-B1 | Dihydro-benzo(1,4)oxazines | AVENTIS PHARMA LTD. (GB) | 2003-10-14 | — | — | US | disclosed |
| EP-1056728-A1 | DIHYDRO-BENZO(1,4)OXAZINES AND TETRAHYDROQUINOXALINES | Aventis Pharma Limited (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-2000039103-A1 | DIHYDRO-BENZO(1,4)OXAZINES AND TETRAHYDROQUINOXALINES | AVENTIS PHARMA LIMITED (GB) | 2000-07-06 | — | — | WO | disclosed |