Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5274873 | 1.00 | HDAC1 (0.46) | HDAC1HDAC3HDAC6MEN1KMT2A | |
| SCHEMBL17183361 | 0.79 | HDAC1 (0.71) | HDAC1HDAC3HDAC6 | |
| SCHEMBL5273140 | 0.79 | HDAC1 (0.71) | HDAC1HDAC3HDAC6 | |
| SCHEMBL2073474 | 0.78 | HDAC1 (0.46) | HDAC1HDAC3HDAC6MEN1KMT2A | |
| SCHEMBL5278894 | 0.77 | HDAC1 (0.45) | HDAC1HDAC3HDAC6MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL2071844 | 0.76 | HDAC1 (0.66) | HDAC1HDAC3HDAC6 | |
| SCHEMBL17183236 | 0.75 | HDAC1 (0.57) | HDAC1HDAC3HDAC6 | |
| SCHEMBL15518473 | 0.74 | HDAC1 (0.65) | HDAC1HDAC3HDAC6 | |
| Hydrochloric Acid SCHEMBL2072808 | 0.74 | HDAC1 (0.45) | HDAC1HDAC3HDAC6UTS2R | |
| Hydrochloric Acid SCHEMBL2073570 | 0.71 | HDAC1 (0.64) | HDAC1HDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828171-A2 | HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006061638-A2 | HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-06-15 | — | — | WO | disclosed |