Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 20/20 | 0.87 |
| ▸ | AKT1 | P31749 | 7/20 | 0.87 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.82 |
| ▸ | INCENP | Q9NQS7 | 6/20 | 0.82 |
| ▸ | AURKA | O14965 | 12/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14974986 | 0.93 | RPS6KB1 (1.00) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL10093525 | 0.91 | RPS6KB1 (1.00) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL14974658 | 0.86 | RPS6KB1 (0.80) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL14974401 | 0.84 | RPS6KB1 (0.82) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL10093526 | 0.84 | RPS6KB1 (0.82) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL14974912 | 0.83 | RPS6KB1 (0.72) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL10093510 | 0.81 | RPS6KB1 (0.72) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL10093520 | 0.81 | RPS6KB1 (1.00) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL526765 | 0.81 | RPS6KB1 (1.00) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL527690 | 0.80 | RPS6KB1 (0.79) | RPS6KB1AKT1AURKBINCENPAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598492-B1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2015-10-28 | — | — | EP | claimed |
| EP-2598492-A1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | Merck Patent GmbH (DE) | 2013-06-05 | — | — | EP | claimed |
| WO-2012013282-A1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | claimed |