Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.49 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523964 | 0.96 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ATRPC3TRPC7 | |
| SCHEMBL2524272 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ATRPC3TRPC7 | |
| SCHEMBL2527780 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ATRPC3TRPC7 | |
| SCHEMBL2527184 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9ATRPC3TRPC7 | |
| SCHEMBL25427148 | 0.76 | TRPC3 (0.50) | SMN1; SMN2NPC1RAB9ATRPC3TRPC7 | |
| SCHEMBL31659003 | 0.76 | TRPC3 (0.50) | SMN1; SMN2NPC1RAB9ATRPC3TRPC7 | |
| SCHEMBL2709584 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AGRIN2BUSP30 | |
| SCHEMBL20135557 | 0.74 | TRPC3 (0.53) | SMN1; SMN2NPC1RAB9ATRPC3TRPC7 | |
| SCHEMBL25291831 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AGRIN2BUSP30 | |
| SCHEMBL6646235 | 0.72 | TNKS (0.53) | SMN1; SMN2NPC1RAB9ATRPC3TRPC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802637-A1 | CGRP RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044504-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-04-27 | — | — | WO | disclosed |