Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286684 | 0.96 | IDO1 (0.58) | IDO1MTNR1AMTNR1BKMT2AMEN1 | |
| Hydroquinone SCHEMBL15387408 | 0.91 | IDO1 (0.53) | IDO1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL18398576 | 0.87 | IDO1 (0.56) | IDO1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL10827236 | 0.87 | IDO1 (0.56) | IDO1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL31072414 | 0.87 | IDO1 (0.56) | IDO1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL16776780 | 0.84 | IDO1 (0.46) | IDO1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL1030014 | 0.84 | IDO1 (0.56) | IDO1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL10834706 | 0.83 | IDO1 (0.49) | IDO1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL6667180 | 0.83 | PPARG (0.58) | IDO1KMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2296213 | 0.82 | MEN1 (0.58) | IDO1MTNR1AMTNR1BKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1504048-B1 | METHOD OF PREPARING POLYESTERCARBONATES | GEN ELECTRIC (US) | 2007-11-21 | — | — | EP | disclosed |
| EP-1504048-A1 | METHOD OF PREPARING POLYESTERCARBONATES | GENERAL ELECTRIC COMPANY (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003087190-A1 | METHOD OF PREPARING POLYESTERCARBONATES | GENERAL ELECTRIC COMPANY (US) | 2003-10-23 | — | — | WO | disclosed |
| US-6600004-B1 | Preparing polyestercarbonates is presented in which a mixture of at least one activated diaryl carbonate is reacted under melt polymerization conditions with at least one aromatic dihydroxy compound together with at least one dicarboxylic | GENERAL ELECTRIC COMPANY | 2003-07-29 | — | — | US | disclosed |