Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25978287 | 0.83 | MEN1 (0.45) | MEN1KMT2AMAPK1GAABTK | |
| SCHEMBL23038833 | 0.83 | MEN1 (0.45) | MEN1KMT2AMAPK1GAABTK | |
| SCHEMBL25978289 | 0.83 | MEN1 (0.45) | MEN1KMT2AMAPK1GAABTK | |
| SCHEMBL2329093 | 0.82 | MEN1 (0.44) | MEN1KMT2AMAPK1GAABTK | |
| SCHEMBL31021350 | 0.80 | KMT2A (0.45) | MEN1KMT2AMAPK1GAABTK | |
| SCHEMBL2074992 | 0.77 | GAA (0.51) | MEN1KMT2AMAPK1GAABTK | |
| SCHEMBL20583619 | 0.76 | BTK (0.45) | MEN1KMT2AMAPK1GAABTK | |
| SCHEMBL15600327 | 0.75 | GAA (0.44) | MEN1KMT2AMAPK1GAABTK | |
| SCHEMBL25979754 | 0.75 | KMT2A (0.39) | MEN1KMT2AMAPK1GAABTK | |
| SCHEMBL31168732 | 0.74 | GAA (0.43) | MEN1KMT2AMAPK1GAABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |