Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL667541 | 0.75 | MAPK14 (1.00) | MAPK14MEN1KMT2AMAPK1MAPT | |
| SCHEMBL3541451 | 0.74 | MAPK14 (0.65) | MAPK14MEN1KMT2AMAPK1MAPT | |
| SCHEMBL10710090 | 0.73 | MEN1 (0.79) | MAPK14MEN1KMT2AMAPK1MAPT | |
| SCHEMBL21253163 | 0.72 | GRIN2C (0.63) | MEN1KMT2AMAPK1MAPTLMNA | |
| SCHEMBL668778 | 0.69 | MAPK14 (1.00) | MAPK14MEN1KMT2AMAPK1MAPT | |
| SCHEMBL21259191 | 0.69 | GLRA3 (0.47) | MEN1KMT2AMAPK1MAPTLMNA | |
| SCHEMBL1514754 | 0.69 | KDM4E (0.75) | MEN1KMT2AMAPK1MAPTLMNA | |
| SCHEMBL3241483 | 0.68 | MAPK14 (0.72) | MAPK14MEN1KMT2AMAPK1 | |
| SCHEMBL10530781 | 0.68 | MEN1 (1.00) | MAPK14MEN1KMT2AMAPK1MAPT | |
| SCHEMBL13556606 | 0.68 | MEN1 (0.59) | MAPK14MEN1KMT2AMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828169-A2 | UREA INHIBITORS OF MAP KINASES | Locus Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006062982-A2 | UREA INHIBITORS OF MAP KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |