Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | ACACB | O00763 | 6/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.45 |
| ▸ | NEK3 | P51956 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | NEK5 | Q6P3R8 | 1/20 | 0.45 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25703284 | 0.83 | HDAC3 (0.49) | MAPTHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL12395356 | 0.82 | HDAC6 (0.61) | MAPTHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL15341329 | 0.81 | MAPT (0.53) | MAPTHDAC6ACACBPOLBSMN1; SMN2 | |
| SCHEMBL23370098 | 0.79 | MAPT (0.54) | MAPTHDAC6ACACBHDAC3HDAC1 | |
| SCHEMBL16663857 | 0.78 | POLB (0.59) | MAPTHDAC6ACACBHDAC3HDAC1 | |
| SCHEMBL25709615 | 0.77 | HDAC6 (0.47) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL186135 | 0.76 | POLB (0.69) | MAPTHDAC6POLBSMN1; SMN2KDM4E | |
| SCHEMBL4790004 | 0.75 | POLB (0.49) | MAPTHDAC6POLBSMN1; SMN2KDM4E | |
| SCHEMBL184998 | 0.74 | POLB (0.71) | MAPTHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL6125266 | 0.74 | HDAC6 (0.65) | MAPTHDAC6SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809290-A2 | PYRIMIDINE DERIVATIVES AS ION CHANNEL MODULATORS AND METHODS OF USE | Vertex Pharmaceuticals Incorporated (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006050476-A2 | PYRIMIDINE DERIVATIVES AS ION CHANNEL MODULATORS AND METHODS OF USE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-11 | — | — | WO | disclosed |