SCHEMBL528068

SCHEMBL528068

CC(C)(Sc1ccccc1F)C(=O)N1CCN(C(=O)c2cc(Cc3nncc4ccccc34)ccc2F)CC1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 20/20 0.47
TNKS O95271 1/20 0.46
ADORA1 P30542 1/20 0.46
CDK6 Q00534 1/20 0.46
PDE3A Q14432 1/20 0.46
PARP6 Q2NL67 1/20 0.46
PARP15 Q460N3 1/20 0.46
PARP14 Q460N5 1/20 0.46
PARP10 Q53GL7 1/20 0.46
TIPARP Q7Z3E1 1/20 0.46
PARP8 Q8N3A8 1/20 0.46
PARP16 Q8N5Y8 1/20 0.46
PARP12 Q9H0J9 1/20 0.46
TNKS2 Q9H2K2 1/20 0.46
PARP11 Q9NR21 1/20 0.46
PARP2 Q9UGN5 1/20 0.46
PARP4 Q9UKK3 1/20 0.46
PARP3 Q9Y6F1 1/20 0.46
PRAP1 Q96NZ9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL524949 0.83 PARP1 (0.71) PARP1TNKSADORA1CDK6PDE3A
SCHEMBL525419 0.83 PARP1 (0.48) PARP1TNKSADORA1CDK6PDE3A
SCHEMBL526826 0.81 PARP1 (0.47) PARP1TNKSADORA1CDK6PDE3A
SCHEMBL22799419 0.81 PARP1 (0.67) PARP1TNKSADORA1CDK6PDE3A
SCHEMBL23113132 0.81 PARP1 (0.66) PARP1TNKSADORA1CDK6PDE3A
SCHEMBL30266813 0.81 PARP1 (0.66) PARP1TNKSADORA1CDK6PDE3A
SCHEMBL526566 0.81 PARP1 (0.46) PARP1TNKSADORA1CDK6PDE3A
SCHEMBL524692 0.80 PARP1 (0.43) PARP1TNKSADORA1CDK6PDE3A
SCHEMBL30396088 0.80 PARP1 (0.52) PARP1TNKSADORA1CDK6PDE3A
SCHEMBL28678813 0.80 PARP1 (0.52) PARP1TNKSADORA1CDK6PDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2598491-A1 SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS Cadila Healthcare Limited (IN) 2013-06-05 EP claimed
WO-2012014221-A1 SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS CADILA HEALTHCARE LIMITED (IN) 2012-02-02 WO claimed