Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.83 |
| ▸ | LTA4H | P09960 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.68 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.68 |
| ▸ | BACE1 | P56817 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | HRH1 | P35367 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491712 | 0.92 | HRH3 (0.97) | HRH3LTA4HKCNH2HRH4BACE1 | |
| SCHEMBL5858684 | 0.91 | HRH3 (0.95) | HRH3LTA4HKCNH2HRH4BACE1 | |
| SCHEMBL21462645 | 0.87 | HRH3 (0.86) | HRH3LTA4HKCNH2HRH4BACE1 | |
| SCHEMBL10676754 | 0.83 | HRH3 (0.97) | HRH3LTA4HKCNH2HRH4HRH1 | |
| SCHEMBL492265 | 0.83 | HRH3 (0.97) | HRH3LTA4HKCNH2HRH4HRH1 | |
| SCHEMBL492176 | 0.83 | HRH3 (0.79) | HRH3KCNH2HRH4KDM4E | |
| SCHEMBL491550 | 0.83 | HRH3 (0.79) | HRH3KCNH2HRH4KDM4E | |
| SCHEMBL491651 | 0.83 | KCNA3 (0.57) | HRH3KCNH2HRH4 | |
| SCHEMBL5280015 | 0.82 | HRH3 (0.79) | HRH3KCNH2HRH4HRH1 | |
| SCHEMBL5857700 | 0.82 | HRH3 (0.94) | HRH3LTA4HKCNH2HRH4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863486-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | claimed |
| WO-2006103537-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | claimed |
| EP-1863486-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103537-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | disclosed |