Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | BCHE | P06276 | 7/20 | 0.59 |
| ▸ | ACHE | P22303 | 7/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | PDE1A | P54750 | 5/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5296696 | 0.85 | HRH3 (0.74) | HRH3 | |
| SCHEMBL5277493 | 0.84 | HRH3 (0.61) | KDM4EALDH1A1ACHEHRH3 | |
| SCHEMBL9360133 | 0.83 | HRH4 (1.00) | HRH4KDM4EALDH1A1BCHEACHE | |
| SCHEMBL491674 | 0.83 | HRH4 (1.00) | HRH4KDM4EALDH1A1BCHEACHE | |
| SCHEMBL7369141 | 0.82 | HRH4 (0.97) | HRH4KDM4EALDH1A1BCHEACHE | |
| Hydrochloric Acid SCHEMBL7407264 | 0.81 | HRH4 (0.95) | HRH4KDM4EALDH1A1BCHEACHE | |
| SCHEMBL9360171 | 0.81 | HRH4 (0.95) | HRH4KDM4EALDH1A1BCHEACHE | |
| SCHEMBL5280171 | 0.80 | HRH3 (0.63) | HRH3 | |
| SCHEMBL9360240 | 0.79 | BCHE (0.78) | BCHEACHE | |
| SCHEMBL13305510 | 0.79 | BCHE (0.77) | KDM4EBCHEACHEHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863486-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | claimed |
| WO-2006103537-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | claimed |
| EP-1863486-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103537-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | disclosed |