Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | VEGFA | P15692 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129614 | 0.89 | TP53 (0.50) | TP53DPP4HDAC1HDAC6VEGFA | |
| SCHEMBL22532823 | 0.89 | TP53 (0.50) | TP53DPP4HDAC1HDAC6VEGFA | |
| SCHEMBL14103789 | 0.89 | VEGFA (0.53) | TP53HDAC1HDAC6VEGFAEGLN1 | |
| SCHEMBL1876106 | 0.88 | TP53 (0.49) | TP53HDAC1HDAC6VEGFAEGLN1 | |
| SCHEMBL4297578 | 0.88 | NR1H2 (0.50) | TP53DPP4HDAC1HDAC6VEGFA | |
| SCHEMBL4158417 | 0.88 | DPP4 (0.49) | TP53DPP4HDAC1HDAC6VEGFA | |
| SCHEMBL1049753 | 0.88 | HDAC1 (0.50) | TP53DPP4HDAC1HDAC6KMT2A | |
| SCHEMBL1081669 | 0.87 | HDAC1 (0.50) | TP53HDAC1HDAC6VEGFAEGLN1 | |
| SCHEMBL2262766 | 0.87 | CYP3A4 (0.52) | TP53DPP4HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL5328156 | 0.86 | TP53 (0.47) | TP53DPP4HDAC1HDAC6VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008144-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |