Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 17/20 | 0.32 |
| ▸ | CA2 | P00918 | 17/20 | 0.32 |
| ▸ | CA9 | Q16790 | 15/20 | 0.32 |
| ▸ | CA12 | O43570 | 5/20 | 0.31 |
| ▸ | CA7 | P43166 | 5/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.31 |
| ▸ | CA3 | P07451 | 4/20 | 0.31 |
| ▸ | CA4 | P22748 | 4/20 | 0.31 |
| ▸ | CA6 | P23280 | 4/20 | 0.31 |
| ▸ | CA5A | P35218 | 4/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707113 | 0.98 | TSHR (0.39) | USP2TSHRKDM4EALDH1A1LMNA | |
| Ammonia Solution, Strong SCHEMBL9017461 | 0.95 | USP2 (0.37) | USP2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL8835614 | 0.95 | USP2 (0.37) | USP2TSHRKDM4EALDH1A1LMNA | |
| Methylamine SCHEMBL29031628 | 0.93 | CA1 (0.36) | USP2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL429966 | 0.83 | — | — | |
| SCHEMBL11293172 | 0.83 | TSHR (0.46) | USP2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL710962 | 0.83 | CA1 (0.39) | USP2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL25630426 | 0.83 | TSHR (0.52) | USP2TSHRKDM4EALDH1A1LMNA | |
| Ammonia Solution, Strong SCHEMBL540865 | 0.81 | TSHR (0.36) | USP2TSHRALDH1A1 | |
| Phosphine SCHEMBL28298470 | 0.81 | TSHR (0.36) | USP2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863446-A2 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS OF LIOTHYRONINE AND METHODS OF MAKING AND USING THE SAME | King Pharmaceuticals Research and Development Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| US-20060246133-A1 | Controlled release pharmaceutical compositions of liothyronine and methods of making and using the same | CREDIT SUISSE AG | 2006-11-02 | — | — | US | disclosed |
| WO-2006105482-A2 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS OF LIOTHYRONINE AND METHODS OF MAKING AND USING THE SAME | KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC. (US) | 2006-10-05 | — | — | WO | disclosed |