Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Linsitinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R known ✓ | P08069 | 16/20 | 0.98 |
| ▸ | INSR known ✓ | P06213 | 2/20 | 0.98 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.98 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.98 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.98 |
| ▸ | LATS1 | O95835 | 1/20 | 0.98 |
| ▸ | LCK | P06239 | 1/20 | 0.98 |
| ▸ | LYN | P07948 | 1/20 | 0.98 |
| ▸ | RET | P07949 | 1/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.98 |
| ▸ | MET | P08581 | 1/20 | 0.98 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.98 |
| ▸ | INSRR | P14616 | 1/20 | 0.98 |
| ▸ | FECH | P22830 | 1/20 | 0.98 |
| ▸ | MARK3 | P27448 | 1/20 | 0.98 |
| ▸ | FLT4 | P35916 | 1/20 | 0.98 |
| ▸ | KDR | P35968 | 1/20 | 0.98 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.98 |
| ▸ | FLT3 | P36888 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Linsitinib SCHEMBL528637 | 1.00 | IGF1R (0.98) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| Linsitinib SCHEMBL29392484 | 0.99 | IGF1R (1.00) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| Linsitinib SCHEMBL400369 | 0.99 | IGF1R (1.00) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| Linsitinib SCHEMBL400735 | 0.99 | IGF1R (1.00) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| Linsitinib SCHEMBL10255925 | 0.99 | IGF1R (1.00) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| Linsitinib SCHEMBL400734 | 0.99 | IGF1R (1.00) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| Linsitinib SCHEMBL14937815 | 0.95 | IGF1R (0.92) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| Linsitinib SCHEMBL14937816 | 0.95 | IGF1R (0.92) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| Linsitinib SCHEMBL1758871 | 0.95 | IGF1R (0.92) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| Linsitinib SCHEMBL14938209 | 0.94 | IGF1R (0.90) | IGF1RINSRMAPK3MAPK1RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598506-A1 | PROCESS FOR THE PREPARATION OF THE COMPOUND OSI - 906 | OSI Pharmaceuticals, LLC (US) | 2013-06-05 | — | — | EP | disclosed |
| US-20130123501-A1 | PROCESS FOR THE PREPARATION OF THE COMPOUND OSI-906 | OSI Pharmaceuticals, LLC | 2013-05-16 | — | — | US | disclosed |
| WO-2012016095-A1 | PROCESS FOR THE PREPARATION OF THE COMPOUND OSI - 906 | OSI Pharmaceuticals, LLC (US) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123501-A1 | PROCESS FOR THE PREPARATION OF THE COMPOUND OSI-906 | ABL1, ERBB2, ALK | IGF1R 379/4885INSR 916/4885MAPK3 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.