Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.49 |
| ▸ | CNR2 | P34972 | 7/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983815 | 0.95 | ALOX5AP (0.52) | ALOX5APCNR2BCHEHDAC6CNR1 | |
| SCHEMBL2977156 | 0.95 | CNR2 (0.54) | ALOX5APCNR2BCHEHDAC6CNR1 | |
| SCHEMBL2987507 | 0.94 | CNR2 (0.56) | ALOX5APCNR2BCHEHDAC6CNR1 | |
| SCHEMBL2985069 | 0.94 | CNR2 (0.56) | ALOX5APCNR2BCHEHDAC6CNR1 | |
| SCHEMBL2982417 | 0.87 | ALOX5AP (0.53) | ALOX5APCNR2HDAC6CNR1KDM4E | |
| SCHEMBL2981592 | 0.85 | ALOX5AP (0.52) | ALOX5APHDAC6KDM4EALDH1A1CYP2C9 | |
| SCHEMBL2977200 | 0.84 | ALOX5AP (0.53) | ALOX5APCNR2HDAC6CNR1 | |
| SCHEMBL4989051 | 0.84 | TP53 (0.52) | ALOX5APCNR2HDAC6CNR1NPC1 | |
| SCHEMBL2976559 | 0.84 | ALOX5AP (0.52) | ALOX5APCNR2BCHEHDAC6CNR1 | |
| SCHEMBL2977135 | 0.83 | ALOX5AP (0.60) | ALOX5APCNR2HDAC6CNR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807398-A1 | NEW INDOLE OR BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006045478-A1 | NEW INDOLE OR BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-04 | — | — | WO | disclosed |