Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 19/20 | 0.57 |
| ▸ | AURKA | O14965 | 11/20 | 0.56 |
| ▸ | AKT1 | P31749 | 2/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528036 | 1.00 | RPS6KB1 (0.57) | RPS6KB1AURKAAKT1PDPK1 | |
| SCHEMBL528783 | 1.00 | RPS6KB1 (0.57) | RPS6KB1AURKAAKT1PDPK1 | |
| SCHEMBL528308 | 1.00 | RPS6KB1 (0.57) | RPS6KB1AURKAAKT1PDPK1 | |
| SCHEMBL15197059 | 0.92 | RPS6KB1 (0.61) | RPS6KB1AURKAAKT1PDPK1 | |
| SCHEMBL18597165 | 0.92 | RPS6KB1 (0.61) | RPS6KB1AURKAAKT1PDPK1 | |
| SCHEMBL527986 | 0.91 | RPS6KB1 (0.57) | RPS6KB1AURKAAKT1PDPK1 | |
| SCHEMBL528082 | 0.91 | RPS6KB1 (0.57) | RPS6KB1AURKAAKT1PDPK1 | |
| SCHEMBL528852 | 0.91 | RPS6KB1 (0.57) | RPS6KB1AURKAAKT1PDPK1 | |
| SCHEMBL527635 | 0.89 | RPS6KB1 (0.73) | RPS6KB1AURKAAKT1PDPK1 | |
| SCHEMBL18845464 | 0.89 | RPS6KB1 (0.73) | RPS6KB1AURKAAKT1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598497-A1 | CYCLIC AMINE AZAHETEROCYCLIC CARBOXAMIDES | Merck Patent GmbH (DE) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016001-A1 | CYCLIC AMINE AZAHETEROCYCLIC CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | disclosed |