Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | PDE6D | O43924 | 1/20 | 0.80 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.71 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3201954 | 0.96 | HMGCR (0.86) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL3201932 | 0.96 | HMGCR (0.86) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL10297391 | 0.96 | HMGCR (0.86) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL3198400 | 0.96 | HMGCR (0.86) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL3210158 | 0.96 | HMGCR (0.86) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL5316885 | 0.96 | HMGCR (0.86) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| Rosuvastatin SCHEMBL247384 | 0.93 | HMGCR (0.92) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL4159337 | 0.90 | HMGCR (0.78) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL4170869 | 0.90 | HMGCR (0.78) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL4209321 | 0.90 | HMGCR (0.78) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863773-A1 | PROCESS FOR PREPARATION OF ROSUVASTATIN | UNICHEM LABORATORIES LIMITED (IN) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006100689-A1 | PROCESS FOR PREPARATION OF ROSUVASTATIN | UNICHEM LABORATORIES LIMITED (IN) | 2006-09-28 | — | — | WO | disclosed |