Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 6/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14974940 | 1.00 | GBA1 (0.46) | GBA1MMP1RORCCA9CA1 | |
| SCHEMBL22115900 | 1.00 | GBA1 (0.46) | GBA1MMP1RORCCA9CA1 | |
| Hydrochloric Acid SCHEMBL17076908 | 0.99 | GBA1 (0.46) | GBA1MMP1RORCCA9CA1 | |
| Hydrochloric Acid SCHEMBL17076909 | 0.99 | GBA1 (0.46) | GBA1MMP1RORCCA9CA1 | |
| Hydrochloric Acid SCHEMBL17076910 | 0.99 | GBA1 (0.46) | GBA1MMP1RORCCA9CA1 | |
| SCHEMBL14974421 | 0.87 | GBA1 (0.55) | GBA1CA9CA1CA2CA5A | |
| SCHEMBL14974422 | 0.87 | GBA1 (0.55) | GBA1CA9CA1CA2CA5A | |
| SCHEMBL27913671 | 0.87 | GBA1 (0.55) | GBA1CA9CA1CA2CA5A | |
| SCHEMBL28088541 | 0.85 | CA9 (0.48) | GBA1CA9CA1CA2CA5A | |
| SCHEMBL28088542 | 0.85 | CA9 (0.48) | GBA1CA9CA1CA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925747-B1 | AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-24 | — | — | EP | disclosed |
| CN-105793254-A | Azaquinazoline carboxamide derivatives | 默克专利有限公司 | 2016-07-20 | — | — | CN | disclosed |
| CN-103003250-B | As the bicyclic nitrogen heterocycles methane amide of kinases P70S6K inhibitor | MERCK PATENT GMBH (DE) | 2016-02-17 | — | — | CN | disclosed |
| EP-2598492-B1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2015-10-28 | — | — | EP | disclosed |
| US-8710044-B2 | Bicyclic azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2014-04-29 | — | — | US | disclosed |
| EP-2598492-A1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | Merck Patent GmbH (DE) | 2013-06-05 | — | — | EP | disclosed |
| US-20130137677-A1 | Bicyclic Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | US | disclosed |
| CN-103003250-A | Bicyclic azaheterocyclic carboxamides as inhibitors of the kinase p70s6k | MERCK PATENT GMBH | 2013-03-27 | — | — | CN | disclosed |
| WO-2012013282-A1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137677-A1 | Bicyclic Azaheterocyclic Carboxamides | CCNI, CCNA1, CCNA2 | GBA1 1051/4885MMP1 3848/4885RORC 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.