Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13202843 | 0.93 | CHRM2 (0.48) | CHRM2HTR2AHRH4NOS2MCHR1 | |
| SCHEMBL2977758 | 0.92 | CHRM2 (0.47) | CHRM2HTR2ACLK4DYRK1ACYP3A4 | |
| SCHEMBL13220856 | 0.88 | CHRM2 (0.43) | CHRM2HTR2AHRH4MAPTNOS2 | |
| SCHEMBL13202773 | 0.88 | CHRM2 (0.43) | CHRM2HTR2AFLT3MAPTNOS2 | |
| SCHEMBL13202888 | 0.86 | MEN1 (0.46) | CHRM2HTR2AMAPTSMN1; SMN2NOS2 | |
| SCHEMBL13202695 | 0.85 | EPAS1 (0.52) | CHRM2ACP1NOS2 | |
| SCHEMBL2977100 | 0.85 | CHRM2 (0.41) | HTTCHRM2HTR2ACLK4CLK1 | |
| SCHEMBL2976590 | 0.85 | ACP1 (0.42) | CHRM2ACP1MAPTNOS2 | |
| SCHEMBL13202698 | 0.80 | HTR2A (0.40) | HTTHTR2AMAPTSMN1; SMN2 | |
| SCHEMBL5279672 | 0.80 | CHRM2 (0.43) | CHRM2ACP1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776847-B2 | Benzisothiazoles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| EP-1853573-A1 | BENZISOTHIAZOLES USEFUL FOR TREATING OR PREVENTING HCV INFECTION | Rigel Pharmaceuticals, Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006091858-A1 | BENZISOTHIAZOLES USEFUL FOR TREATING OR PREVENTING HCV INFECTION | RIGEL PHARMACEUTICALS, INC. (US) | 2006-08-31 | — | — | WO | disclosed |