Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 6/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.49 |
| ▸ | INSR | P06213 | 7/20 | 0.49 |
| ▸ | IGF1R | P08069 | 6/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | STK25 | O00506 | 1/20 | 0.49 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | CASK | O14936 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099480 | 0.87 | ZAP70 (0.68) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12729023 | 0.81 | ZAP70 (0.71) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12780529 | 0.81 | ALK (0.74) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL381697 | 0.79 | ZAP70 (0.76) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL4089455 | 0.79 | ALK (0.72) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL4089491 | 0.79 | ZAP70 (0.70) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL1911961 | 0.78 | EGFR (0.65) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL10207615 | 0.78 | ALK (0.61) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12729029 | 0.77 | ZAP70 (0.75) | ZAP70EGFRALKINSRIGF1R | |
| SCHEMBL12892759 | 0.76 | ZAP70 (0.69) | ZAP70EGFRALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784392-A2 | PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021454-A2 | PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2006-03-02 | — | — | WO | disclosed |