Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 9/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.51 |
| ▸ | INSR | P06213 | 4/20 | 0.51 |
| ▸ | IGF1R | P08069 | 4/20 | 0.51 |
| ▸ | ROS1 | P08922 | 5/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | MET | P08581 | 2/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | STK25 | O00506 | 1/20 | 0.51 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | CASK | O14936 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | MUSK | O15146 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099825 | 0.87 | ALK (0.68) | ZAP70ALKINSRIGF1RROS1 | |
| SCHEMBL4089332 | 0.86 | ZAP70 (0.58) | ZAP70ALKINSRIGF1RROS1 | |
| SCHEMBL4099147 | 0.83 | ZAP70 (0.71) | ZAP70ALKINSRIGF1RROS1 | |
| SCHEMBL4103366 | 0.83 | ZAP70 (0.71) | ZAP70ALKINSRIGF1RROS1 | |
| SCHEMBL12892718 | 0.82 | ALK (0.60) | ZAP70ALKINSRIGF1RROS1 | |
| SCHEMBL4099900 | 0.81 | EGFR (0.70) | ZAP70ALKINSRIGF1RROS1 | |
| SCHEMBL13850478 | 0.80 | ALK (0.74) | ZAP70ALKINSRIGF1RROS1 | |
| SCHEMBL4089365 | 0.80 | ALK (0.69) | ZAP70ALKINSRIGF1RROS1 | |
| SCHEMBL12780216 | 0.79 | ZAP70 (0.78) | ZAP70ALKINSRIGF1RROS1 | |
| SCHEMBL12780186 | 0.79 | ALK (0.62) | ZAP70ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784392-A2 | PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021454-A2 | PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2006-03-02 | — | — | WO | disclosed |