Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 16/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | ATR | Q13535 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15197555 | 0.89 | KCNH2 (0.55) | MELKMAPK1KCNH2ATMATR | |
| SCHEMBL530003 | 0.86 | MELK (0.65) | MELKMAPK1RXFP1 | |
| SCHEMBL15191195 | 0.85 | MAPK1 (0.66) | MELKMAPK1GAANPSR1RXFP1 | |
| SCHEMBL15191392 | 0.85 | MELK (0.53) | MELKMAPK1KCNH2ATMATR | |
| SCHEMBL15191488 | 0.85 | MELK (0.70) | MELKMAPK1GAANPSR1RXFP1 | |
| SCHEMBL15191489 | 0.85 | MELK (0.70) | MELKMAPK1GAANPSR1RXFP1 | |
| SCHEMBL531961 | 0.82 | MELK (0.84) | MELK | |
| SCHEMBL529576 | 0.82 | MELK (0.71) | MELK | |
| SCHEMBL15191143 | 0.80 | MAPK1 (0.64) | MELKMAPK1GAANPSR1RXFP1 | |
| SCHEMBL27907343 | 0.80 | MAPK1 (0.47) | MELKMAPK1KCNH2ATMATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |