SCHEMBL529630

SCHEMBL529630

O=C(O)C=CC=C(C(=O)O)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.44
TP53 P04637 1/20 0.44
EGLN1 Q9GZT9 1/20 0.44
EGLN3 Q9H6Z9 1/20 0.44
ALDH1A1 P00352 3/20 0.42
TDP1 Q9NUW8 3/20 0.42
ALOX15 P16050 2/20 0.42
RECQL P46063 2/20 0.42
HSD17B10 Q99714 2/20 0.42
PTGS1 P23219 1/20 0.36
PTPN1 P18031 1/20 0.34
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
GABRR1 P24046 2/20 0.32
GABRR2 P28476 2/20 0.32
BLM P54132 2/20 0.32
GABRR3 A8MPY1 1/20 0.32
LMNA P02545 1/20 0.32
APEX1 P27695 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL529628 1.00 TSHR (0.44) TSHRTP53EGLN1EGLN3ALDH1A1
SCHEMBL27770604 0.79 TSHR (0.33) TSHRTP53EGLN1EGLN3ALDH1A1
SCHEMBL27770605 0.79 TSHR (0.33) TSHRTP53EGLN1EGLN3ALDH1A1
SCHEMBL454525 0.77 TSHR (0.44) TSHRTP53EGLN1EGLN3ALDH1A1
SCHEMBL19379407 0.77 TSHR (0.44) TSHRTP53EGLN1EGLN3ALDH1A1
SCHEMBL454524 0.77 TSHR (0.44) TSHRTP53EGLN1EGLN3ALDH1A1
Oxalic Acid SCHEMBL5806860 0.74 TSHR (0.57) TSHRTP53EGLN1EGLN3ALDH1A1
Oxalic Acid SCHEMBL5806857 0.74 TSHR (0.57) TSHRTP53EGLN1EGLN3ALDH1A1
SCHEMBL17856797 0.73 TSHR (0.33) TSHRTP53EGLN1EGLN3LMNA
SCHEMBL351491 0.73 TSHR (0.67) TSHRTP53EGLN1EGLN3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116234434-A Plant growth promoting system of radiation quantum energy 云海ENC(株) 2023-06-06 CN claimed
US-8367859-B2 Cyclohexane 1,4 carboxylates Amyris, Inc. (US) 2013-02-05 US claimed
US-20260021148-A1 METHODS FOR ENHANCING IMMUNE CHECKPOINT BLOCKADE THERAPY BY MODULATING THE MICROBIOME BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-01-22 US disclosed
US-20250195469-A1 COMPANION DIAGNOSTICS AND STRATEGIES FOR TREATMENT WITH AN ARYL HYDROCARBON RECEPTOR AGONIST COMPOUND AZORA THERAPEUTICS, INC. 2025-06-19 US disclosed
US-12318413-B2 Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-06-03 US disclosed
EP-4531860-A1 PYRIMIDINONE COMPOUNDS FOR TREATING ACUTE INFLAMMATION Tes Pharma S.r.l. (IT) 2025-04-09 EP disclosed
EP-4493930-A1 COMPANION DIAGNOSTICS AND STRATEGIES FOR TREATMENT WITH AN ARYL HYDROCARBON RECEPTOR AGONIST COMPOUND AZORA THERAPEUTICS, INC. (US) 2025-01-22 EP disclosed
US-20240058268-A1 METHODS OF TREATING SKIN DISORDERS Galderma Holding SA (CH) 2024-02-22 US disclosed
WO-2023227666-A1 PYRIMIDINONE COMPOUNDS FOR TREATING ACUTE INFLAMMATION TES PHARMA S.R.L. (IT) 2023-11-30 WO disclosed
WO-2023178288-A1 COMPANION DIAGNOSTICS AND STRATEGIES FOR TREATMENT WITH AN ARYL HYDROCARBON RECEPTOR AGONIST COMPOUND AZORA THERAPEUTICS, INC. (US) 2023-09-21 WO disclosed
US-20230233620-A1 HIGH-COMPLEXITY SYNTHETIC GUT BACTERIAL COMMUNITIES Kanvas Biosciences, Inc. 2023-07-27 US disclosed
US-4673646-A Production of 2-hydroxymuconic semialdehyde CELANESE CORPORATION (US) 1987-06-16 US disclosed
US-4654303-A Construction of novel mutant microorganisms CELANESE CORPORATION (US) 1987-03-31 US disclosed
EP-0074169-B1 MICRO-BIOLOGICAL PRODUCTION OF MUCONIC ACID CELANESE CORPORATION (US) 1987-01-14 EP disclosed
US-4617156-A 2-hydroxymuconic semialdehyde bisulfite adduct CELANESE CORPORATION (US) 1986-10-14 US disclosed
US-4588688-A Process for the production of muconic acid CELANESE CORPORATION (US) 1986-05-13 US disclosed
EP-0138391-A1 Construction of novel mutant micro-organisms CELGENE CORPORATION (US) 1985-04-24 EP disclosed
EP-0074169-A1 Micro-biological production of muconic acid CELANESE CORPORATION (US) 1983-03-16 EP disclosed
EP-0071446-A2 Construction of microorganisms CELANESE CORPORATION (US) 1983-02-09 EP disclosed
US-4355107-A Production of muconic acid CELANESE CORPORATION (US) 1982-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260021148-A1 METHODS FOR ENHANCING IMMUNE CHECKPOINT BLOCKADE THERAPY BY MODULATING THE MICROBIOME PDCD1, CD274, PDCD1LG2 TSHR 1153/4885TP53 652/4885EGLN1 3713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.