Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 14/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
| ▸ | WEE1 | P30291 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL529836 | 0.84 | MELK (0.53) | MELKHTT | |
| SCHEMBL17434968 | 0.83 | MELK (0.74) | MELK | |
| SCHEMBL10281917 | 0.83 | MELK (0.73) | MELK | |
| SCHEMBL17434839 | 0.81 | MELK (0.75) | MELK | |
| SCHEMBL530055 | 0.81 | MELK (0.72) | MELKCDK2FLT3CCNA1 | |
| SCHEMBL529513 | 0.77 | MELK (0.48) | MELKCDK2FLT3CCNA1HTT | |
| SCHEMBL529139 | 0.75 | CDK2 (0.51) | MELKCDK2FLT3CCNA1WEE1 | |
| SCHEMBL529740 | 0.74 | MELK (0.72) | MELK | |
| SCHEMBL530493 | 0.73 | MELK (0.71) | MELK | |
| SCHEMBL17434992 | 0.73 | MELK (0.79) | MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-B1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE INC (JP) | 2016-01-20 | — | — | EP | disclosed |
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |