Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPA1 | O60313 | 1/20 | 0.61 |
| ▸ | EIF5B | O60841 | 1/20 | 0.61 |
| ▸ | MET | P08581 | 1/20 | 0.61 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1395846 | 1.00 | OPA1 (0.61) | OPA1EIF5BMETHMOX2MEN1 | |
| SCHEMBL1395775 | 0.90 | OPA1 (0.63) | OPA1EIF5BMETHMOX2MEN1 | |
| SCHEMBL15872111 | 0.90 | OPA1 (0.63) | OPA1EIF5BMETHMOX2MEN1 | |
| SCHEMBL1395820 | 0.87 | OPA1 (0.60) | OPA1EIF5BMETHMOX2MEN1 | |
| SCHEMBL2875549 | 0.86 | OPA1 (0.48) | OPA1EIF5BMETHMOX2MEN1 | |
| SCHEMBL13248816 | 0.86 | OPA1 (0.48) | OPA1EIF5BMETHMOX2MEN1 | |
| SCHEMBL1395828 | 0.85 | OPA1 (0.73) | OPA1EIF5BMETHMOX2ALDH1A1 | |
| SCHEMBL3773941 | 0.85 | OPA1 (0.64) | OPA1EIF5BMETHMOX2KMT2A | |
| SCHEMBL1395781 | 0.85 | OPA1 (0.64) | OPA1EIF5BMETHMOX2ALDH1A1 | |
| SCHEMBL1395825 | 0.85 | OPA1 (0.64) | OPA1EIF5BMETHMOX2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846406-A1 | MALEIMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ArQule, Inc. (US) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006086484-A1 | MELEIMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ARQULE, INC. (US) | 2006-08-17 | — | — | WO | disclosed |