Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3744434 | 0.90 | MAPT (0.46) | MAPTMCHR1RXFP1THRBTP53 | |
| SCHEMBL3743907 | 0.79 | MAPT (0.47) | MAPTMCHR1RXFP1THRBTP53 | |
| Hydrochloric Acid SCHEMBL3748748 | 0.78 | MAPT (0.47) | MAPTMCHR1RXFP1THRBTP53 | |
| SCHEMBL3743699 | 0.78 | HDAC6 (0.47) | MAPTMCHR1RXFP1THRBTP53 | |
| SCHEMBL3754747 | 0.77 | MCHR1 (0.63) | MAPTMCHR1RXFP1THRBTP53 | |
| SCHEMBL3746952 | 0.74 | HDAC6 (0.45) | MAPTMCHR1RXFP1THRBTP53 | |
| SCHEMBL5247226 | 0.74 | MCHR1 (0.61) | MAPTMCHR1RXFP1THRBTP53 | |
| SCHEMBL14100023 | 0.73 | HDAC6 (0.43) | MAPTMCHR1RXFP1THRBTP53 | |
| SCHEMBL3746679 | 0.72 | MAPT (0.61) | MAPTMCHR1RXFP1THRBTP53 | |
| Hydrochloric Acid SCHEMBL3743909 | 0.72 | HDAC6 (0.42) | MAPTMCHR1RXFP1THRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066173-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-06-22 | — | — | WO | disclosed |