Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9578379 | 0.90 | IKBKB (0.81) | IKBKBKDM4EGFERKMT2ARXFP1 | |
| SCHEMBL3794862 | 0.86 | IKBKB (0.76) | IKBKBKDM4EGFERKMT2ARXFP1 | |
| SCHEMBL3781950 | 0.85 | IKBKB (1.00) | IKBKBKDM4EGFERKMT2ARXFP1 | |
| SCHEMBL14566191 | 0.84 | KMT2A (0.58) | IKBKBKDM4EGFERKMT2ARXFP1 | |
| SCHEMBL1805758 | 0.84 | IKBKB (0.55) | IKBKBKDM4EGFERKMT2ARXFP1 | |
| SCHEMBL5300577 | 0.83 | IKBKB (0.71) | IKBKBKDM4EGFERKMT2ARXFP1 | |
| SCHEMBL5308529 | 0.83 | IKBKB (0.71) | IKBKBKDM4EGFERKMT2ARXFP1 | |
| SCHEMBL10713802 | 0.82 | KMT2A (0.84) | IKBKBKDM4EGFERKMT2ARXFP1 | |
| Terephthalamide SCHEMBL28048082 | 0.82 | KMT2A (0.57) | IKBKBKDM4EGFERKMT2ARXFP1 | |
| SCHEMBL5306999 | 0.81 | CHUK (0.70) | IKBKBKDM4EGFERKMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025575-A1 | O-HYDROXY- AND O-AMINO BENZAMIDE DERIVATIVES AS IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007025575-A1 | O-HYDROXY- AND O-AMINO BENZAMIDE DERIVATIVES AS IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |