Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.68 |
| ▸ | TNKS | O95271 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.63 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.63 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.63 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.63 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.63 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.63 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.63 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.63 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.63 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.63 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.63 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.63 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.63 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.63 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528072 | 0.94 | PARP1 (0.70) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL526432 | 0.94 | PARP1 (0.72) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL527533 | 0.93 | PARP1 (0.69) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL525674 | 0.92 | PARP1 (0.66) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL524849 | 0.89 | PARP1 (0.66) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL526724 | 0.89 | PARP1 (0.68) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL525872 | 0.89 | PARP1 (0.68) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL527193 | 0.89 | PARP1 (0.67) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL524949 | 0.88 | PARP1 (0.71) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL524884 | 0.88 | PARP1 (0.57) | PARP1TNKSADORA1CDK6PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598491-B1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS | CADILA HEALTHCARE LTD (IN) | 2015-09-02 | — | — | EP | claimed |
| US-8871765-B2 | Substituted 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one derivatives as poly (ADP-ribose) polymerase-1 inhibitors | CADILA HEALTHCARE LIMITED (IN) | 2014-10-28 | — | — | US | claimed |
| US-20130137695-A1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1-CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE-1 INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2013-05-30 | — | — | US | claimed |
| EP-2598491-B1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS | CADILA HEALTHCARE LTD (IN) | 2015-09-02 | — | — | EP | disclosed |
| US-8871765-B2 | Substituted 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one derivatives as poly (ADP-ribose) polymerase-1 inhibitors | CADILA HEALTHCARE LIMITED (IN) | 2014-10-28 | — | — | US | disclosed |
| EP-2598491-A1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS | Cadila Healthcare Limited (IN) | 2013-06-05 | — | — | EP | disclosed |
| US-20130137695-A1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1-CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE-1 INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2013-05-30 | — | — | US | disclosed |
| WO-2012014221-A1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137695-A1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1-CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE-1 INHIBITORS | PARP1, PARP2, PARP11 | PARP1 1/4885TNKS 14/4885ADORA1 2662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.