Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.45 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3223162 | 0.92 | SRC (0.58) | SRCMAP2K1FYNEGFRMAP3K8 | |
| SCHEMBL3215862 | 0.86 | SRC (0.58) | SRCMAP2K1FYNEGFRMAP3K8 | |
| SCHEMBL3223428 | 0.82 | SRC (0.59) | SRCMAP2K1FYNEGFR | |
| SCHEMBL6739314 | 0.82 | SRC (0.57) | SRCMAP2K1FYNEGFR | |
| SCHEMBL3229483 | 0.80 | SRC (0.72) | SRCMAP2K1FYNEGFR | |
| SCHEMBL3229269 | 0.80 | SRC (0.56) | SRCMAP2K1FYNEGFR | |
| SCHEMBL3231242 | 0.79 | MAP2K1 (0.61) | SRCMAP2K1FYNEGFRMAP3K8 | |
| SCHEMBL3215925 | 0.78 | SRC (0.55) | SRCMAP2K1FYNEGFRMAP3K8 | |
| SCHEMBL3223410 | 0.77 | SRC (0.69) | SRCMAP2K1FYNEGFR | |
| SCHEMBL3228144 | 0.76 | MAP2K1 (0.53) | SRCMAP2K1FYNEGFRMAP3K8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-B1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-08-29 | — | — | EP | claimed |