Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.55 |
| ▸ | TNF | P01375 | 5/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.55 |
| ▸ | HCK | P08631 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | RAF1 | P04049 | 2/20 | 0.55 |
| ▸ | LYN | P07948 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | MUSK | O15146 | 1/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29593381 | 0.84 | MAPK14 (0.76) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL296487 | 0.84 | MAPK14 (0.76) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL20876925 | 0.84 | MAPK14 (0.76) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6735307 | 0.80 | ABL1 (0.56) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6732717 | 0.78 | ABL1 (0.74) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6302094 | 0.78 | TNF (0.73) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6302092 | 0.78 | TNF (0.73) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL7968631 | 0.78 | MAPK14 (0.48) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6807988 | 0.78 | ABL1 (0.51) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6807983 | 0.78 | ABL1 (0.61) | MAPK14TNFMAPK12MAPK13MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784224-A2 | EGFR KINASE INHIBITOR COMBINATIONS FOR TREATING RESPIRATORY AND GASTROINTESTINAL DISORDERS | Boehringer Ingelheim International GmbH (DE) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006015775-A2 | EGFR KINASE INHIBITOR COMBINATIONS FOR TREATING RESPIRATORY AND GASTROINTESTINAL DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-02-16 | — | — | WO | disclosed |