Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 13/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | CCR4 | P51679 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17159812 | 0.85 | CYP19A1 (0.80) | CYP19A1HDAC1HDAC6 | |
| SCHEMBL11354103 | 0.82 | CYP19A1 (0.69) | CYP19A1KMT2AMEN1ALDH1A1HDAC1 | |
| Hydrochloric Acid SCHEMBL11358575 | 0.80 | CYP19A1 (0.67) | CYP19A1KMT2AMEN1ALDH1A1HDAC1 | |
| SCHEMBL15688800 | 0.80 | CYP19A1 (0.71) | CYP19A1HDAC1HDAC6 | |
| SCHEMBL9525426 | 0.79 | KDM4E (0.50) | CYP19A1ALDH1A1HDAC1HDAC6 | |
| SCHEMBL3235365 | 0.78 | CYP19A1 (0.69) | CYP19A1HDAC1HDAC6 | |
| SCHEMBL31415788 | 0.77 | HRH4 (0.45) | CYP19A1KMT2ATSHRMAPK1HSD17B10 | |
| Hydrochloric Acid SCHEMBL11347612 | 0.77 | CYP19A1 (0.67) | CYP19A1ALDH1A1HDAC1HDAC6 | |
| SCHEMBL306232 | 0.77 | CYP19A1 (0.67) | CYP19A1HDAC1HDAC6 | |
| SCHEMBL307542 | 0.77 | CYP19A1 (0.67) | CYP19A1ALDH1A1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |