Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPA1 | O60313 | 1/20 | 0.66 |
| ▸ | EIF5B | O60841 | 1/20 | 0.66 |
| ▸ | MET | P08581 | 1/20 | 0.66 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1395827 | 1.00 | OPA1 (0.66) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL1395828 | 0.90 | OPA1 (0.73) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL3773941 | 0.89 | OPA1 (0.64) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL1395825 | 0.89 | OPA1 (0.64) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL1395821 | 0.89 | OPA1 (0.66) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL1395726 | 0.89 | OPA1 (0.66) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL1720158 | 0.89 | OPA1 (0.66) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL15872111 | 0.86 | OPA1 (0.63) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL1395775 | 0.86 | OPA1 (0.63) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL1395847 | 0.85 | OPA1 (0.61) | OPA1EIF5BMETHMOX2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846406-A1 | MALEIMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ArQule, Inc. (US) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006086484-A1 | MELEIMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ARQULE, INC. (US) | 2006-08-17 | — | — | WO | disclosed |